Whole Exome Sequencing Study of Thyrotropin Secreting Pituitary Adenomas
نویسندگان
چکیده
منابع مشابه
Whole-exome sequencing identifies variants in invasive pituitary adenomas
Pituitary adenomas exhibit a wide range of behaviors. The prediction of invasion or malignant behavior in pituitary adenomas remains challenging. The objective of the present study was to identify the genetic abnormalities associated with invasion in sporadic pituitary adenomas. In the present study, the exomes of six invasive pituitary adenomas (IPA) and six non-invasive pituitary adenomas (nI...
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Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune system disorder characterized by uncontrolled hyper-inflammation owing to hypercytokinemia from the activated but ineffective cytotoxic cells. Establishing a correct diagnosis for HLH patients due to the similarity of this disease with other conditions like malignant lymphoma and leukemia and similarity among its two forms is dif...
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Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10-15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developin...
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(SHBG): 73 nmol/l (normal, 13 to 71). His serum testosterone and the cortisol response on cosyntropin stimulation testing were normal. A presumptive diagnosis of a thyrotropin and growth hormone co-secreting pituitary adenoma was made. Octreotide LAR therapy was advised preoperatively to control thyroid hormone excess. He underwent transsphenoidal resection of the sellar mass, which was consist...
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ژورنال
عنوان ژورنال: The Kitakanto Medical Journal
سال: 2018
ISSN: 1343-2826,1881-1191
DOI: 10.2974/kmj.68.105